Exploring the Role Of NAD+ Supplements in Cardiovascular Disease


Others call it the molecule of youth, while to most it is NAD+. No one wants to pass on anything that can increase their lifespan even for a minute more. Due to compelling lifestyle activities that condone unhealthy lives, such as eating highly processed foods, it is important therefore that you consider increasing your NAD+ through supplementation.

NAD+ Intermediates

When you supplement with NAD+ intermediates, you will automatically increase NAD+ in the cells and mitochondria. This can go a long way towards reversing numerous diseases or aging processes that come with low NAD+. Here are some of the NAD+ intermediates:

  • Niacinamide in low doses
  • Nicotinamide Mononucleotide (MNM)
  • Aspartic and Tryptophan acid will fuel NAD+. This can still be found through amino acids from dietary protein
  • Nicotinamide Riboside (NR)
  • Cardiovascular Disease and NAD+

Increase in age is the number one factor for developing cardiovascular disease; CVD. Did you know that cardiovascular disease is the main cause of morbidity and mortality in both industrial and post-industrial societies?

Key Drivers for Cardiovascular Disease

The surge in cardiovascular disease with age is largely driven by adversative changes to the arteries. This is especially due to stiffening of the aorta, which increases systolic pressure. Therefore, interventions designed to decrease blood pressure and enhance arterial function are highly promising in preventing age-related cardiovascular disease.

Chronic Calorie Restriction (CR)

This is one of the strategies one can use to prevent cardiovascular disease. CR is said to prevent arterial dysfunction, and increase blood pressure with aging. It is further claimed that adherence to calorie restriction can lower arterial stiffness as well as pressure in obese and overweight middle-aged and older adults.

But even with all the health benefits, adhering to chronic CR has been a challenge to the successful implementation of this regime. It is also considered to be unsafe for older adults with normal weights. It therefore still leaves the need to establish safer, hands-on alternatives to the regular CR. This will go a long way to enhance cardiovascular functions plus health in aging human beings.

NAD+ and Calorie Restriction

Recently, several important molecular mechanisms were identified to be behind the long term regulation of calorie restriction in model organisms. This has led to promising search for calorie restriction solutions to enhance cardiovascular and physiological functions in aging humans.

In this case, nicotinamide adenine dinucleotide (NAD+) has been discovered to be an important signaling molecule (electron carrier) and indispensible substrate for sirtuins. Sirtuins are a class of enzymes that help in activating the numerous advantages of calorie restriction in model organisms, inclusive of maintaining cardiovascular function. In pre-clinical models, calorie restriction has been found to increase NAD+ levels.

The bioavailability of NAD+ and its metabolites in cells typically declines in humans with natural aging. This can contribute to physiological aging by decreasing sirtuin activity. This situation can be countered through the oral supplementation using one of the two NAD+ metabolites:

  • Nicotinamide mononucleotide
  • Nicotinamide riboside

This will go a long way towards improving levels of NAD+ as well as enhancing multiple physiological functions in people.

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